| Novel targets for inflammatory bowel disease therapeutics. | |
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MedLine Citation:
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PMID: 23314806 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In recent years, many new agents have been evaluated for the treatment of inflammatory bowel disease. In this paper, we critically review recently published literature about these novel therapies, which have been the result of extensive research identifying molecular targets. Of the various biologicals and small molecules that have recently been tested in clinical trials, several demonstrated clinical efficacy with a tolerable safety profile. We discuss a number of them with specific focus on vedolizumab, a monoclonal antibody directed against the alpha4beta7 integrin on lymphocytes, ustekinumab, a monoclonal antibody against the p40 subunit of interleukin-12 and interleukin-23, and tofacitinib, a small molecule targeting Janus-activated kinase. Most likely, these three agents will find their way to the market and offer significant therapeutic alternatives for the management of Crohn's disease and/or ulcerative colitis. |
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Authors:
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Mark Löwenberg; Geert D'Haens |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current gastroenterology reports Volume: 15 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 311 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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