| Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression. | |
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MedLine Citation:
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PMID: 15242839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function. |
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Authors:
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Faina Schwartz; Arvi Duka; Irena Duka; Jing Cui; Haralambos Gavras |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2004-07-08 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 287 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-11 Completed Date: 2004-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1957-66 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, Genetics Program, Boston Univ. School of Medicine, 715 Albany St., L-320, Boston, MA 02118, USA. fschw@bu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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physiology* Animals Gene Expression / physiology* Gene Expression Profiling / methods* Genome Male Mice Mice, Inbred C57BL Myocardium / metabolism* Reverse Transcriptase Polymerase Chain Reaction Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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P50-HL-55001/HL/NHLBI NIH HHS; U01-HL-66617/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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