| Novel systemic therapeutic for nasopharyngeal carcinoma. | |
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MedLine Citation:
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PMID: 22313344 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Systemic therapy is crucial to the management of locally advanced or metastatic nasopharyngeal cancer (NPC). Despite initial responses, the benefits of conventional chemotherapy are seldom durable and the toxicities are intolerable to most patients. Therefore, novel therapies based on molecular targets of NPC have become the focus of development. Areas covered: Three novel therapeutics, targeting EGFR, angiogenic processes and epigenetic dysregulation, are discussed in this review. The scientific basis and latest published results of clinical trials are also highlighted. Expert opinion: In summary, cetuximab, an anti-EGFR monoclonal antibody shows promising results in both locally advanced and metastatic disease. Anti-angiogenic therapy such as sunitinib is efficacious but hemorrhagic complications are of concern in selected patients. Finally, translational studies demonstrate that epigenetic therapeutics could restore the immunogenicity of Epstein-Barr virus in NPC cells. For anti-EGFR therapy, the promising results in early clinical trials should be validated in Phase III clinical trials. Better selection of patients and safer therapy is necessary in future development of anti-angiogenic therapy for NPC. Early clinical trials on epigenetic therapeutics are in process and results are eagerly awaited. |
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Authors:
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Stephen L Chan; Brigette B Ma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-8 |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: - ISSN: 1744-7631 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Chinese University of Hong Kong, Hong Kong Cancer Institute and Prince of Wales Hospital, Sir YK Pao Center for Cancer, Department of Clinical Oncology , State Key Laboratory in Oncology in South China, Shatin , Hong Kong +852 2648 7097 ; Brigette@clo.cuhk.edu.hk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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