| Novel synthesis of N(4)-substituted 1,4-benzodiazepine-2,5-diones using poly(ethylene glycol) as soluble polymer support. | |
| | |
MedLine Citation:
|
PMID: 17168679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An efficient method for the liquid-phase combinatorial synthesis of N4-substituted 1,4-benzodiazepine-2,5-diones has been developed. Poly(ethylene glycol) (PEG) stepwise reacted with bromoacetyl bromide, a primary amine and 2-azidobenzoic acid to give a potential PEG-bound dipeptide, which was reduced by NaI / acetic acid, along with concurrent cyclization and cleavage of the seven-membered heterocycle from the PEG support. |
| | |
Authors:
|
Zhen Rao; Hongdan Peng; Guichun Yang; Zuxing Chen |
Related Documents
:
|
2700999 - The use of dentinal etching with endodontic bleaching procedures. 10196799 - Effects of acid-etching on the tensile properties of demineralized dentin matrix. 9581289 - In vitro biosynthesis of poly(3-hydroxybutyric acid) by using purified poly(hydroxyalka... 18970259 - Biocompatible polymers for antibody support on gold surfaces. 11562199 - Pretargeting with amplification using polymeric peptide nucleic acid. 12500789 - Mechanical characteristics of an absorbable copolymer internal fixation pin. 11453999 - Structure and characterization of the glycan moiety of l-amino-acid oxidase from the ma... 19429429 - Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic... 11498029 - Peptaibols: models for ion channels. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Combinatorial chemistry & high throughput screening Volume: 9 ISSN: 1386-2073 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-12-15 Completed Date: 2007-03-07 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 743-6 Citation Subset: IM |
Affiliation:
|
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Faculty of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Benzodiazepines
/
chemical synthesis*,
chemistry* Combinatorial Chemistry Techniques* Molecular Structure Nitrogen / chemistry* Polyethylene Glycols / chemistry* Solubility |
| Chemical | |
Reg. No./Substance:
|
0/Bz-423; 0/Polyethylene Glycols; 12794-10-4/Benzodiazepines; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities...
Next Document: Selective molecularly imprinted polymer obtained from a combinatorial library for the extraction of ...