| Novel strategies for the treatment of inflammatory hyperalgesia. | |
| | |
MedLine Citation:
|
PMID: 20155257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity (hyperalgesia).The current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflammation. Also, the inflammatory mediators that interact with neurons to produce hyperalgesia are explored. As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability, elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain, with improved specificity, efficacy, and possibly with fewer toxic effects. |
| | |
Authors:
|
Atul R Chopade; Wahid A Mulla |
Related Documents
:
|
22166927 - Association of modic changes, schmorl's nodes, spondylolytic defects, high intensity zo... 10946477 - Malingering and symptom magnification: a case report illustrating the limitations of cl... 7659247 - Orofacial pain resulting from ill-fitting dentures. 16099397 - Lipid mediators regulating pain sensitivity. 7858357 - Pain in young adults: i. relationship to gender and family pain history. 15507807 - Hip-spine syndrome: total sagittal alignment of the spine and clinical symptoms in pati... |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-02-13 |
Journal Detail:
|
Title: European journal of clinical pharmacology Volume: 66 ISSN: 1432-1041 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-13 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: Germany |
Other Details:
|
Languages: eng Pagination: 429-44 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Taluka: Walwa, Sangli, 415404, Maharashtra, India. chopadearv@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesics
/
pharmacology,
therapeutic use* Animals Anti-Inflammatory Agents / pharmacology, therapeutic use* Drug Delivery Systems / methods Humans Hyperalgesia / drug therapy*, metabolism Inflammation / complications*, drug therapy* Inflammation Mediators / metabolism* Neurons, Afferent / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population.
Next Document: Giant Aneurysms Associated with Aortic Coarctation: Management Challenges and Options.