Document Detail


Novel strategies for the treatment of inflammatory hyperalgesia.
MedLine Citation:
PMID:  20155257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity (hyperalgesia).The current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflammation. Also, the inflammatory mediators that interact with neurons to produce hyperalgesia are explored. As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability, elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain, with improved specificity, efficacy, and possibly with fewer toxic effects.
Authors:
Atul R Chopade; Wahid A Mulla
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-13
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  66     ISSN:  1432-1041     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  429-44     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Taluka: Walwa, Sangli, 415404, Maharashtra, India. chopadearv@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology,  therapeutic use*
Animals
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Drug Delivery Systems / methods
Humans
Hyperalgesia / drug therapy*,  metabolism
Inflammation / complications*,  drug therapy*
Inflammation Mediators / metabolism*
Neurons, Afferent / drug effects
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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