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Novel stain-free lecithinized coal tar formulation for psoriasis.
MedLine Citation:
PMID:  21671911     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  Coal tar has been a very popular traditional treatment for various types of psoriasis for over a century. It is the first-line treatment for scalp, hand, and foot psoriasis. However, the application of coal tar on hair invariably causes staining, which results in a high degree of patient non-compliance, especially in patients with non-black hair. Thus, the treatment of scalp psoriasis with a topical coal tar formulation requires that special concern be paid to product esthetics. Objective  This study aimed to evaluate the hair-staining characteristics of a novel lecithinized coal tar (LCT) formulation on different types of mammalian hair. Methods  Samples of hair from different mammals, including human, sheep, rabbit, and goat, were repeatedly exposed to the LCT formulation over 14 days. The color of hair samples treated with LCT was compared with that of untreated control hair samples. Results  The study revealed the distinct non-staining potential of the LCT formulation. Conclusions  This LCT formulation lacks the propensity to stain hair and thus has excellent potential to be exploited in the treatment of scalp psoriasis.
Authors:
Amit Bhatia; Bhupinder Singh; Basant Amarji; Poonam Negi; Anshuman Shukla; Om Prakash Katare
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-15
Journal Detail:
Title:  International journal of dermatology     Volume:  -     ISSN:  1365-4632     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The International Society of Dermatology.
Affiliation:
Drug Delivery Research Group, University Institute of Pharmaceutical Sciences (UGC), University Grants Commission, Centre of Advanced Study, Panjab University, Chandigarh, India.
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