| Novel spherical phantoms for Q-ball imaging under in vivo conditions. | |
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MedLine Citation:
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PMID: 20740652 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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For the validation of complex diffusion imaging techniques like q-ball imaging that aim to resolve multiple fiber directions, appropriate phantoms are highly desirable. However, previous q-ball imaging phantoms had diffusion anisotropies well below those of in vivo white matter. In this work, fiber phantoms of well-defined geometry are presented. The fibers are wound on a spherical spindle yielding high packing densities and consequently high diffusion anisotropies (fractional anisotropy 0.93 ± 0.02 at b = 500 s/mm(2)). Phantoms with 90° and 45° crossing angle were constructed both with two crossing types. In the "stacked" crossing, two fiber strings were wound consecutively to simulate two touching fibers, in the "interleaved" crossing, fibers were wound alternately. The stacked crossing allows the alteration of partial volumes, whereas the interleaved crossing provides constant partial volumes, allowing e.g. the easy alteration of the SNR by varying the slice thickness. Exemplary q-ball imaging validation measurements using different b-values and slice thicknesses are presented. |
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Authors:
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Amir Moussavi-Biugui; Bram Stieltjes; Klaus Fritzsche; Wolfhard Semmler; Frederik B Laun |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 65 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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