| Novel solid lipid nanoparticles as carriers for oral administration of insulin. | |
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MedLine Citation:
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PMID: 19827297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to propose novel solid lipid nanoparticles (SLNs) loaded with cell-penetrating peptide (CPP), and to evaluate their potential for oral administration of insulin. Octaarginine (R8) was used as the CPP. SLNs loaded with insulin and R8 (Ra-Ins-SLNs) were prepared using the spontaneous emulsion solvent diffusion method. The morphological study of R8-Ins-SLNs showed its spherical shape using transmission electron microscopy (TEM) photography. The mean particle size, zeta potential, encapsulation efficiency (EE %) of insulin and R8 were 150.8 +/- 23.4 nm, 32.65 +/- 2.02 mV, 62.29 +/- 0.52% and 58.05 +/- 0.66%, respectively. The in vitro release of insulin or R8 from R8-Ins-SLNs was characterized by an initial rapid release and subsequent sustained release in pH 6.8 dissolution media. In vivo absorption experiments provided a relative pharmacological bioavailability (PA%) value of R8-Ins-SLN of 10.39 +/- 0.46%. These results suggest that SLNs loaded with CPP could be a promising perioral carrier for insulin. |
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Authors:
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Zhenhai Zhang; Huixia Lv; Jianping Zhou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 64 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 574-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical, China Pharmaceutical University, Nanjing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Pharmaceutical Drug Carriers* Drug Compounding Electrochemistry Emulsions Hypoglycemic Agents / administration & dosage* Insulin / administration & dosage* Intestinal Absorption Liposomes Male Microscopy, Electron, Transmission Nanoparticles* Particle Size Rats Rats, Sprague-Dawley Solubility |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Emulsions; 0/Hypoglycemic Agents; 0/Liposomes; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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