| Novel sialic acid transporter of Haemophilus influenzae. | |
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MedLine Citation:
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PMID: 16113244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nontypeable Haemophilus influenzae is an opportunistic pathogen and a common cause of otitis media in children and of chronic bronchitis and pneumonia in patients with chronic obstructive pulmonary disease. The lipooligosaccharides, a major component of the outer membrane of H. influenzae, play an important role in microbial virulence and pathogenicity. N-Acetylneuraminic acid (sialic acid) can be incorporated into the lipooligosaccharides as a terminal nonreducing sugar. Although much of the pathway of sialic acid incorporation into lipooligosaccharides is understood, the transporter responsible for N-acetylneuraminic acid uptake in H. influenzae has yet to be characterized. In this paper we demonstrate that this transporter is a novel sugar transporter of the tripartite ATP-independent periplasmic transporter family. In the absence of this transporter, H. influenzae cannot incorporate sialic acid into its lipooligosaccharides, making the organism unable to survive when exposed to human serum and causing reduced viability in biofilm growth. |
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Authors:
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Simon Allen; Anthony Zaleski; Jason W Johnston; Bradford W Gibson; Michael A Apicella |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 73 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-10-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 5291-300 Citation Subset: IM |
Affiliation:
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Buck Institute for Age Research, 8001 Redwood Blvd., Novato, California 94945, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/DQ054469; DQ054470; DQ054471 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biofilms Biological Transport Electrophoresis, Polyacrylamide Gel Haemophilus influenzae / genetics, metabolism* Lipopolysaccharides / metabolism Molecular Sequence Data N-Acetylneuraminic Acid / metabolism* Organic Anion Transporters / genetics, isolation & purification, metabolism* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Symporters / genetics, isolation & purification, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI24616/AI/NIAID NIH HHS; AI30040/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Organic Anion Transporters; 0/Symporters; 0/lipid-linked oligosaccharides; 0/sialic acid transport proteins; 131-48-6/N-Acetylneuraminic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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