Document Detail


Novel resistin promoter polymorphisms: association with serum resistin level in Japanese obese individuals.
MedLine Citation:
PMID:  15326567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Resistin, an adipocyte-secreted cytokine recently discovered in mice, has been proposed as a link between obesity and diabetes. We analyzed resistin gene polymorphisms and examined their association with serum resistin level and obesity phenotypes in humans. SUBJECTS AND METHODS: Sixty young, obese, non-diabetic subjects taking no medication were studied. DNA sequencing and genotyping of identified single nucleotide polymorphisms were performed. Associations between polymorphisms and serum resistin level, BMI, body composition, fat distribution, and several indices of insulin sensitivity were examined. Moreover, single nucleotide polymorphisms in the promoter region were examined for their influence on resistin gene transcriptional activity using luciferase reporter vectors. RESULTS: Ten non-coding single nucleotide polymorphisms were found. The -638G>A, -420C>G, and -358G>A polymorphisms in the promoter region showed marked linkage disequilibrium with each other, and were associated with serum resistin level; however, there was no association between these polymorphisms and parameters related to adiposity or insulin resistance. The results of luciferase assay revealed that -638G>A together with the -420C>G polymorphism influenced resistin gene transcriptional activity. CONCLUSION: We found that variability in the serum resistin level might be related to polymorphic variants of the promoter region of the gene.
Authors:
K Azuma; S Oguchi; Y Matsubara; T Mamizuka; M Murata; H Kikuchi; K Watanabe; F Katsukawa; H Yamazaki; A Shimada; T Saruta
Related Documents :
12175537 - Multiplex pcr for simultaneous detection of 677 c-->t and 1298 a-->c polymorphisms in m...
9622337 - Obesity related phenotypes in families selected for extreme obesity and leanness.
19346767 - Obesity in emerging nations: evolutionary origins and the impact of a rapid nutrition t...
11320527 - A screen for mutations in human homologues of mice exencephaly genes tfap2alpha and msx...
12771857 - Prevalence of the g20210a prothrombin gene mutation in northwestern greece and associat...
21889777 - Histomolecular classification of adult diffuse gliomas: the diagnostic value of immunoh...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  36     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2005-02-14     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  564-70     Citation Subset:  IM    
Affiliation:
Department of Internal Mecicine, School of Medicine, Keio University, Tokyo, Japan. SNA12474@nifty.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenine
Adult
Asian Continental Ancestry Group / genetics*
Cytosine
Female
Guanine
Hormones, Ectopic / blood*,  genetics*
Humans
Linkage Disequilibrium
Male
Obesity / blood*,  genetics*
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Promoter Regions, Genetic / genetics*
Resistin
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Hormones, Ectopic; 0/RETN protein, human; 0/Resistin; 71-30-7/Cytosine; 73-24-5/Adenine; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active g...
Next Document:  Infusion of beta-endorphin improves insulin resistance in fructose-fed rats.