Document Detail


Novel renal amino acid transporters.
MedLine Citation:
PMID:  15709970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reabsorption of amino acids, similar to that of glucose, is a major task of the proximal kidney tubule. Various amino acids are actively transported across the luminal brush border membrane into proximal tubule epithelial cells, most of which by cotransport. An important player is the newly identified cotransporter (symporter) B0AT1 (SLC6A19), which imports a broad range of neutral amino acids together with Na+ across the luminal membrane and which is defective in Hartnup disorder. In contrast, cationic amino acids and cystine are taken up in exchange for recycled neutral amino acids by the heterodimeric cystinuria transporter. The basolateral release of some neutral amino acids into the extracellular space is mediated by unidirectional efflux transporters, analogous to GLUT2, that have not yet been definitively identified. Additionally, cationic amino acids and some other neutral amino acids leave the cell basolaterally via heterodimeric obligatory exchangers.
Authors:
François Verrey; Zorica Ristic; Elisa Romeo; Tamara Ramadan; Victoria Makrides; Mital H Dave; Carsten A Wagner; Simone M R Camargo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  67     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  557-72     Citation Subset:  IM    
Affiliation:
University of Zurich, Institute of Physiology, CH-8057 Zurich, Switzerland. verrey@access.unizh.ch
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport Systems / metabolism*
Animals
Humans
Kidney / metabolism*
Chemical
Reg. No./Substance:
0/Amino Acid Transport Systems

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