Document Detail

Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex.
MedLine Citation:
PMID:  9486824     Owner:  NLM     Status:  MEDLINE    
We have identified a novel receptor-like protein tyrosine phosphatase (RPTPrho) transcript whose expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Acidic fibroblast growth factor (FGF-1) mRNA follows a similar cerebellar expression pattern. Together, the two markers define a sharp boundary in lobule 6, slightly caudal to the primary fissure. Anterior and posterior compartments became discernible only during postnatal weeks two and six, for RPTPrho and FGF-1, respectively. A rostrocaudal boundary in lobule 6 of the murine cerebellar cortex has also been identified morphologically by the effects of the meander tail mutation. The position of the RPTPrho and FGF-1 boundary on the rostrocaudal axis of the cerebellar cortex was close to, but not coincident with, the caudal extent of the disorganized anterior lobe of meander tail and the rostral extent of Otx-2 expression. The restricted pattern of FGF-1 and RPTPrho implies that these molecules may have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.
P E McAndrew; A Frostholm; J E Evans; D Zdilar; D Goldowitz; I M Chiu; A H Burghes; A Rotter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  391     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-27     Completed Date:  1998-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  444-55     Citation Subset:  IM    
Department of Neurology, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
Biological Markers / chemistry
Cerebellar Cortex / chemistry*,  cytology,  embryology
Embryonic and Fetal Development / physiology
Fibroblast Growth Factor 1 / genetics*
Genes, Homeobox
Mesencephalon / chemistry*,  embryology
Mice, Inbred C57BL
Neurons / chemistry
Protein Tyrosine Phosphatases / genetics*
RNA, Messenger / analysis*
Receptors, Cell Surface / genetics*
Rhombencephalon / chemistry*,  embryology
Signal Transduction / physiology
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/RNA, Messenger; 0/Receptors, Cell Surface; 104781-85-3/Fibroblast Growth Factor 1; EC Tyrosine Phosphatases

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