| Novel rat model of stress urinary incontinence with a retroflexed bladder. | |
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MedLine Citation:
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PMID: 20062975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION AND HYPOTHESIS: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence. METHODS: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy. RESULTS: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased. CONCLUSION: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence. |
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Authors:
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Naoki Kawamorita; Yasuhiro Kaiho; Haruo Nakagawa; Minoru Miyazato; Mabumi Matsushita; Yoichi Arai |
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Publication Detail:
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Type: Journal Article Date: 2010-01-09 |
Journal Detail:
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Title: International urogynecology journal Volume: 21 ISSN: 1433-3023 ISO Abbreviation: Int Urogynecol J Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-07-15 Revised Date: 2011-08-18 |
Medline Journal Info:
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Nlm Unique ID: 101567041 Medline TA: Int Urogynecol J Country: England |
Other Details:
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Languages: eng Pagination: 595-601 Citation Subset: IM |
Affiliation:
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Department of Urology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal* Female Pressure Rats Rats, Sprague-Dawley Urinary Bladder / abnormalities Urinary Incontinence, Stress / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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