Document Detail

Novel rat model of stress urinary incontinence with a retroflexed bladder.
MedLine Citation:
PMID:  20062975     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION AND HYPOTHESIS: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence.
METHODS: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy.
RESULTS: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased.
CONCLUSION: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.
Naoki Kawamorita; Yasuhiro Kaiho; Haruo Nakagawa; Minoru Miyazato; Mabumi Matsushita; Yoichi Arai
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Publication Detail:
Type:  Journal Article     Date:  2010-01-09
Journal Detail:
Title:  International urogynecology journal     Volume:  21     ISSN:  1433-3023     ISO Abbreviation:  Int Urogynecol J     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-07-15     Revised Date:  2011-08-18    
Medline Journal Info:
Nlm Unique ID:  101567041     Medline TA:  Int Urogynecol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  595-601     Citation Subset:  IM    
Department of Urology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
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MeSH Terms
Disease Models, Animal*
Rats, Sprague-Dawley
Urinary Bladder / abnormalities
Urinary Incontinence, Stress / etiology

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