Document Detail


Novel putative promoter/enhancer sequences are shared by the mouse and human perforin (Pfp) genes.
MedLine Citation:
PMID:  2095003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes the organization of the mouse pore-forming protein (perforin) gene (Pfp), which is highly analogous to that of the corresponding human gene. Pfp comprises three exons, the first of which consists entirely of 5' non-coding sequence, separated by an intron of 1.94 kb from the two polypeptide-coding exons. The promoter region of the gene shows strong similarity to that in humans, with six stretches of high homology noted within 0.7 kb of the mRNA cap site. However, many of the sequences of the human gene with similarity to previously described promoter/enhancer elements are poorly conserved in the mouse, suggesting that these motifs may be of no functional significance, and that control mechanisms for expression of Pfp may be highly specific to killer cells.
Authors:
J A Trapani; B Dupont
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Tissue antigens     Volume:  36     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-07-02     Completed Date:  1991-07-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Melbourne, Parkville, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Enhancer Elements, Genetic*
Exons
Gene Expression Regulation
Genes
Humans
Killer Cells, Natural / metabolism
Lymphocyte Activation
Membrane Glycoproteins*
Membrane Proteins / genetics*
Mice / genetics*
Molecular Sequence Data
Perforin
Pore Forming Cytotoxic Proteins
Promoter Regions, Genetic*
RNA Caps / genetics
Regulatory Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Species Specificity
Grant Support
ID/Acronym/Agency:
CA-22507/CA/NCI NIH HHS; CA-49096/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Membrane Proteins; 0/Pore Forming Cytotoxic Proteins; 0/RNA Caps; 126465-35-8/Perforin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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