| Novel putative promoter/enhancer sequences are shared by the mouse and human perforin (Pfp) genes. | |
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MedLine Citation:
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PMID: 2095003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the organization of the mouse pore-forming protein (perforin) gene (Pfp), which is highly analogous to that of the corresponding human gene. Pfp comprises three exons, the first of which consists entirely of 5' non-coding sequence, separated by an intron of 1.94 kb from the two polypeptide-coding exons. The promoter region of the gene shows strong similarity to that in humans, with six stretches of high homology noted within 0.7 kb of the mRNA cap site. However, many of the sequences of the human gene with similarity to previously described promoter/enhancer elements are poorly conserved in the mouse, suggesting that these motifs may be of no functional significance, and that control mechanisms for expression of Pfp may be highly specific to killer cells. |
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Authors:
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J A Trapani; B Dupont |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Tissue antigens Volume: 36 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-07-02 Completed Date: 1991-07-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: DENMARK |
Other Details:
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Languages: eng Pagination: 228-34 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Melbourne, Parkville, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Enhancer Elements, Genetic* Exons Gene Expression Regulation Genes Humans Killer Cells, Natural / metabolism Lymphocyte Activation Membrane Glycoproteins* Membrane Proteins / genetics* Mice / genetics* Molecular Sequence Data Perforin Pore Forming Cytotoxic Proteins Promoter Regions, Genetic* RNA Caps / genetics Regulatory Sequences, Nucleic Acid Sequence Homology, Nucleic Acid Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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CA-22507/CA/NCI NIH HHS; CA-49096/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Membrane Proteins; 0/Pore Forming Cytotoxic Proteins; 0/RNA Caps; 126465-35-8/Perforin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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