Document Detail

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators.
MedLine Citation:
PMID:  23151189     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Prostaglandins and their G-protein coupled receptors play numerous physiological and pathophysiological roles especially in inflammation and its resolution. The variety of physiological effects mediated by prostanoids makes prostanoid receptors valuable drug targets and the research on prostaglandin receptor modulators is intensive. Prostaglandin receptor targeting drugs might be beneficial for the treatment of inflammatory, allergic, respiratory and cardiovascular disorders as well as treatment of pain but several novel fields of use such as cancer and ophthalmic diseases have also been found apart from these classical indications.
AREAS COVERED: Evaluation of the patent activity over the last decade (2002 - 2012) illustrates many potent and selective modulators of the distinct prostanoid receptors and some novel methods for their use besides the classical indications. By now, some prostaglandin receptor antagonists already have reached clinical development.
EXPERT OPINION: Though the structural diversity of compounds targeting prostanoid receptors is not really large, several highly potent agents with favorable properties have been developed. The clinical potential of FP, IP, TP and DP modulators remains to be investigated, while first very promising clinical results are available as far as CRTH2 is concerned.
Christina Lamers; Daniel Flesch; Manfred Schubert-Zsilavecz; Daniel Merk
Related Documents :
9258869 - Postnatal ontogeny of glutamate receptors in the rat nucleus tractus solitarii and vent...
7730989 - Nmda receptor-mediated sympathetic chemoreflex excitation of rvl-spinal vasomotor neuro...
24172649 - Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurg...
24065879 - Pgrmc1 and pgrmc2 in uterine physiology and disease.
1676329 - Developmental expression of excitatory amino acid responses in cerebellar purkinje neur...
12010199 - Role of excitatory amino acid inputs to the rostral ventrolateral medulla in cardiovasc...
18304029 - Nuclear trafficking of the g-protein-coupled parathyroid hormone receptor.
20109269 - Expression of melatonin (mt1, mt2) and melatonin-related receptors in the adult rat tes...
10516629 - Evidence for a role for central 5-ht2b as well as 5-ht2a receptors in cardiovascular re...
Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-14
Journal Detail:
Title:  Expert opinion on therapeutic patents     Volume:  23     ISSN:  1744-7674     ISO Abbreviation:  Expert Opin Ther Pat     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-06-04     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9516419     Medline TA:  Expert Opin Ther Pat     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-77     Citation Subset:  IM    
Goethe University Frankfurt am Main, Frankfurt, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Design*
Molecular Targeted Therapy
Patents as Topic
Prostaglandins / metabolism*
Receptors, Prostaglandin / drug effects*,  metabolism
Reg. No./Substance:
0/Prostaglandins; 0/Receptors, Prostaglandin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nitrogen fertilization of the host plant influences production and pathogenicity of Botrytis cinerea...
Next Document:  Systemic associations of dynamic retinal vessel analysis: a review of current literature.