Document Detail

Novel preharvest strategies involving the use of experimental chlorate preparations and nitro-based compounds to prevent colonization of food-producing animals by foodborne pathogens.
MedLine Citation:
PMID:  15844824     Owner:  NLM     Status:  MEDLINE    
Foodborne diseases caused by enterohemorrhagic Escherichia coli, Salmonella, and Campylobacter species are of public health and economic significance. Shedding of these pathogens during production and slaughter are risks for contamination of products for human consumption. Consequently, strategies are sought to prevent or reduce the carriage of these pathogens in food animals before slaughter. Experimental products containing chlorate salts have been proven efficacious in reducing concentrations of E. coli and Salmonella Typhimurium in the gut of cattle, sheep, swine, and poultry when administered as feed or water additives. Mechanistically, chlorate selectively targets bacteria expressing respiratory nitrate reductase activity, such as most members of the family Enterobacteriaceae, as this enzyme catalyzes the reduction of chlorate to lethal chlorite. Most beneficial gut bacteria lack respiratory nitrate reductase activity, and thus the technology appears compatible with many bacteria exhibiting competitive exclusion capabilities. More recently, select nitrocompounds have been investigated as potential feed additives, and although these nitrocompounds significantly reduce pathogens on their own, evidence indicates that they may most effectively be used to complement the bactericidal activity of chlorate. A particularly attractive aspect of the nitrocompound technology is that, as potent inhibitors of ruminal methanogenesis, they may allow producers the opportunity to recoup costs associated with their use. At present, neither chlorate nor the nitrocompounds have been approved as feed additives by the US Food and Drug Administration, and consequently they are not yet available for commercial use.
R C Anderson; R B Harvey; J A Byrd; T R Callaway; K J Genovese; T S Edrington; Y S Jung; J L McReynolds; D J Nisbet
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Poultry science     Volume:  84     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-54     Citation Subset:  IM    
United States Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, College Station, Texas 77845, USA.
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MeSH Terms
Animal Feed*
Animal Husbandry*
Chlorates / administration & dosage*,  pharmacology
Food Microbiology / standards*
Nitrogen Compounds / administration & dosage*,  pharmacology
Reg. No./Substance:
0/Chlorates; 0/Nitrogen Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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