Document Detail


Novel polypeptides induced by the insecticide lindane (gamma-hexachlorocyclohexane) are required for its biodegradation by a Sphingomonas paucimobilis strain.
MedLine Citation:
PMID:  8630034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When exposed to the potent insecticide gamma-hexachlorocyclohexane or lindane, a Sphingomonas paucimobilis strain rapidly synthesized 7 novel polypeptides and concomitantly gained the ability to degrade lindane. Synthesis of these proteins was switched-off subsequent to the disappearance of lindane from the medium. Treatments which induced the synthesis of identical proteins also conferred on cells the ability to degrade lindane. In contrast, cells blocked in protein synthesis could not be induced to degrade lindane. The close correspondence observed between expression of lindane-induced proteins and gamma-hexachlorocyclohexane catabolism strongly implicates these novel proteins in lindane biodegradation.
Authors:
T K Adhya; S K Apte; K Raghu; N Sethunathan; N B Murthy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  221     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-61     Citation Subset:  IM    
Affiliation:
Division of Soil Science and Microbiology, Central Rice Research Institute, Cuttack, India.
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MeSH Terms
Descriptor/Qualifier:
Biodegradation, Environmental
Insecticides / metabolism,  pharmacology*
Lindane / metabolism,  pharmacology*
Peptide Biosynthesis*
Pseudomonas / metabolism*
Chemical
Reg. No./Substance:
0/Insecticides; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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