| Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery. I. Physicochemical characterization of the carboxymethyl konjac glucomannan-chitosan nanoparticles. | |
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MedLine Citation:
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PMID: 15739184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carboxymethyl konjac glucomannan-chitosan (CKGM-CS) nanoparticles, which are well dispersed and stable in aqueous solution, were spontaneously prepared under very mild conditions via polyelectrolyte complexation. The physicochemical properties of the nanoparticles were identified by Zetasizer 3000 and Fourier transform infrared. It was found that at various CKGM and CS concentrations the particles ranged in size from approximately 50 to 1200 nm, and the zeta potential from 15 to 45 mV. By changing pH value of the medium and increasing the concentration of salt, the mean size of the particles increased and the zeta potential decreased. Also, investigations on the encapsulation efficiency of the bovine serum albumin loaded CKGM-CS nanoparticles were also undertaken. This nanoparticulate system driven by complex formation shows potential as an advanced drug delivery system for water-soluble drugs. |
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Authors:
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Jian Du; Rui Sun; Sheng Zhang; Li-Fang Zhang; Cheng-Dong Xiong; Yu-Xing Peng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biopolymers Volume: 78 ISSN: 0006-3525 ISO Abbreviation: Biopolymers Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-07 Completed Date: 2005-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372525 Medline TA: Biopolymers Country: United States |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chitosan
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chemistry* Drug Delivery Systems* Electrolytes / chemistry* Hydrogen-Ion Concentration Mannans / chemistry* Molecular Structure Molecular Weight Nanostructures* Nanotechnology / methods* Serum Albumin, Bovine / chemistry Spectroscopy, Fourier Transform Infrared Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Mannans; 0/Serum Albumin, Bovine; 0/konjac gluco-mannan; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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