| Novel pharmacologic therapies in development for acute decompensated heart failure. | |
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MedLine Citation:
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PMID: 23314727 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Acute heart failure is a public health issue with morbidity and mortality exceeding that of myocardial infarction. Novel compounds for the treatment of acute heart failure are clearly needed and fall into the general categories of inotropic, vasodilatory and other compounds in phase I to III of development. Furthest along are omecamtiv mecarbil (a cardiac myosin activator), ularitide (a natriuretic and diuretic peptide) and relaxin (a vasodilator). Each compound has a unique set of assets and liabilities that will aid in the understanding of the syndrome and application to the right patients at the right time in this heterogeneous syndrome. This review will explore current and future novel pharmacologic therapies for the treatment of acute heart failure. |
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Authors:
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Justin A Ezekowitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current cardiology reports Volume: 15 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 329 Citation Subset: IM |
Affiliation:
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Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada, justin.ezekowitz@ualberta.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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