| Novel paediatric anticoagulants: a review of the current literature. | |
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MedLine Citation:
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PMID: 20135753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are many limitations with respect to anticoagulants currently used in standard paediatric practice for prophylaxis and treatment of thrombosis: heparin, low molecular-weight heparin, and warfarin. Factors such as pharmacokinetic and dosing variability are further exacerbated by properties of the immature haemostatic system of children. These shortcomings necessitate exploring alternative anticoagulants in the paediatric population. In this review, we discuss several promising direct thrombin inhibitors and factor Xa inhibitors, and synthesize relevant drug information and clinical experience from the limited available case reports, case series, and nonrandomized dose-finding trials published to date. |
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Authors:
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Veronica H T Chan; Paul Monagle; Patti Massicotte; Anthony K C Chan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 21 ISSN: 1473-5733 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 144-51 Citation Subset: IM |
Affiliation:
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Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Child Clinical Trials as Topic Factor Xa / antagonists & inhibitors* Humans Thrombin / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; EC 3.4.21.5/Thrombin; EC 3.4.21.6/Factor Xa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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