Document Detail


Novel oral anticoagulants in acute coronary syndrome.
MedLine Citation:
PMID:  22989603     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide with a prevalence that has now reached pandemic levels as a consequence of the rapid modernization of the developing world. Its presentation as an acute coronary syndrome (ACS) is a frequent reason for hospital admission and of profound implications for personal, societal and global health. Despite improvements in the management of ACS with anti-platelet and anticoagulant therapy and revascularization techniques, many patients continue to suffer recurrent ischemic events. The need to reduce future cardiovascular events has led to the development of novel therapies to prevent coronary thrombosis, targeting thrombin-mediated pathways. These include direct Xa inhibitors (apixaban, rivaroxaban and darexaban), direct thrombin inhibitors (dabigatran) and PAR 1 antagonists (vorapaxar and atopaxar). This article critically reviews the comparative mechanisms of action, the risks and benefits, together with the clinical evidence base for the use of these novel oral agents in the management of ACS patients.
Authors:
Charis Costopoulos; Maria Niespialowska-Steuden; Neville Kukreja; Diana A Gorog
Related Documents :
6982143 - Postoperative monitoring of myocardial oxygen tension: experience in 51 coronary artery...
3572783 - Systemic and regional hemodynamic effects of isomazole in awake dogs with congestive he...
12765983 - Clinical and analytical performance of the liaison cardiac troponin i assay in unstable...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-15
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
E&N Hertfordshire NHS Trust, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemical profiling of seized methamphetamine putatively synthesized from phenylacetic acid derivativ...
Next Document:  Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated pr...