| Novel nucleolar antigens in autoimmune disease. | |
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MedLine Citation:
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PMID: 2441047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antinucleolar antibodies are of interest in 2 important areas, namely, autoimmune diseases and specific products involved in the "mitogenic cascade." The former have delineated a series of novel nuclear and nucleolar elements including the recently described proliferating cell nuclear antigens (PCNA), some of which are present in the nucleolus only at specific times in the G1-S phase of the cell cycle. Important new proteins such as "fibrillarin" (34 kD/pI 8.5) and a 125 kD nucleotide containing protein have been identified with antinucleolar antibodies. Protein p145 is a nucleolar PCNA that is present in growing and dividing cells but not in normal resting tissues. Antinucleolar antibodies offer powerful tools, not only for identification of specific nucleolar proteins important in the cell cycle, but also for purification of their genes and analysis of mechanisms of gene control that operate the "time windows" of the cell cycle. |
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Authors:
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H Busch; R K Busch; A Black; P K Chan; A Chatterjee; E Durban; J Freeman; R Ochs; M Reichlin; E M Tan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of rheumatology. Supplement Volume: 14 Suppl 13 ISSN: 0380-0903 ISO Abbreviation: J Rheumatol Suppl Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-09-21 Completed Date: 1987-09-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806058 Medline TA: J Rheumatol Suppl Country: CANADA |
Other Details:
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Languages: eng Pagination: 70-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Antibodies, Monoclonal / immunology Antibody Specificity Antigens, Neoplasm / immunology Autoantibodies / immunology Autoantigens / immunology* Autoimmune Diseases / immunology* Cell Nucleolus / immunology* Epitopes / immunology Hela Cells Humans Nuclear Proteins* Phosphoproteins / immunology Ribonucleoproteins / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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CA-10893, P1/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/Autoantibodies; 0/Autoantigens; 0/Epitopes; 0/Nuclear Proteins; 0/Phosphoproteins; 0/Ribonucleoproteins; 0/malignancy-associated nucleolar antigen, human; 117896-08-9/nucleophosmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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