| Novel nonantibiotic therapies for pneumonia: cytokines and host defense. | |
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MedLine Citation:
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PMID: 11171779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effective host defense against bacterial infection is dependent on the activation and recruitment of phagocytic cells. The initiation, maintenance, and resolution of this inflammatory response in the setting of bacterial pneumonia is dependent on the expression of cytokines. As the complexities of the host-pathogen interaction are further dissected and unraveled, immunologic manipulation of cytokine expression will likely become an important adjuvant therapy in the treatment of serious lung infections. |
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Authors:
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S Nelson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Chest Volume: 119 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 419S-425S Citation Subset: AIM; IM |
Affiliation:
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Louisiana State University Health Sciences Center, Department of Medicine, 1901 Perdido St., New Orleans, LA 70112, USA. snelso1@lsuhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Therapy* Cross Infection / immunology, therapy* Cytokines* / drug effects, physiology, therapeutic use Granulocyte Colony-Stimulating Factor / pharmacology, physiology Humans Interleukin-10 / pharmacology, physiology Interleukin-12 / pharmacology, physiology Interleukin-8 / pharmacology, physiology Pneumonia, Bacterial / immunology, therapy* Tumor Necrosis Factor-alpha / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 143011-72-7/Granulocyte Colony-Stimulating Factor; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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