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A NOVEL, NON-INVASIVE TRANSDERMAL FLUID SAMPLING METHODOLOGY: IGF-I MEASUREMENT FOLLOWING EXERCISE.
MedLine Citation:
PMID:  21389329     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study tested the hypothesis that transdermal fluid (TDF) is more sensitive than serum to exercise-induced increases in insulin-like growth factor-I (IGF-I) concentration, and that these increases would be evident proximal, but not distal, to the exercising muscle. A novel, non-invasive methodology was used to collect TDF for analysis. TDF and serum concentrations of total IGF-I (tIGF-I) and free IGF-I (fIGF-I) were measured following an acute bout of exercise. Experiment 1: Eight men (23 ± 3 yrs, 79 ± 7 kg, mean ± SD,) underwent two conditions (resting and 60 minutes of cycling exercise at 60% VO(2peak)) in which serum and forearm TDF were collected for comparison. There were no significant changes in tIGF-I or fIGF-I in forearm TDF or serum following the cycling exercise (P > 0.05). To determine whether exercise-induced increases in local IGF-I could be detected in TDF sampled directly over exercising muscles, we performed a second experiment. Experiment 2: Fourteen subjects (22 ± 4 yrs, 149 ± 49 lbs, mean ± SD) underwent an acute plyometric exercise condition consisting of ten sets of ten plyometric jumps with a two-minute rest period between sets. We observed a significant increase in thigh TDF tIGF-I following exercise (P ≤ 0.05), with no change in serum tIGF-I (P > 0.05). Overall, these data suggest that TDF may provide a non-invasive means of monitoring acute exercise-induced changes in local IGF-I when sampled in proximity to exercising muscles.
Authors:
Dennis Edward Scofield; Holly L McClung; James P McClung; William J Kraemer; Kevin R Rarick; Joseph R Pierce; Gregory J Cloutier; Roger A Fielding; Ronald W Matheny; Andrew J Young; Bradley C Nindl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1U.S. Army Research Institute of Environmental Medicine.
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