Document Detail


Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization.
MedLine Citation:
PMID:  22269665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Late-term thrombosis associated with drug-eluting stents may be due to the non-selective actions of antimitogenic drugs on endothelial cells, leading to delayed vascular healing after stenting angioplasty. Currently, there is a need for stent-based therapies that can both attenuate neointimal hyperplasia and promote re-endothelialization. The aim of this study was to compare the effects of a resveratrol (R)- and quercetin (Q)-eluting stent with that of a bare metal stent (BMS) on neointimal hyperplasia and re-endothelialization in a rat model of arterial angioplasty and stenting. Miniature stents (2.5×1.25mm) were sprayed with nanocomposite coatings containing two concentrations of R:Q (50:25μg/cm(2) (RQ1) or 150:75μg/cm(2) (RQ2)). The stents were deployed into the common carotid artery of rats and their impact on vascular remodeling was compared to that of BMS. Luminal stenosis in arteries stented with RQ2-eluting stents was reduced by 64.6% (p<0.05) compared to arteries stented with BMS. Accompanying this effect was a 59.8% reduction in macrophage infiltration (p<0.05). There were no differences found between RQ1 and BMS. Finally, the RQ2-coated stent accelerated re-endothelialization by 50% compared with BMS (p<0.05). Thus, compared with BMS, local delivery of R and Q from a stent platform significantly reduced in-stent stenosis, while promoting re-endothelialization. These data suggest that R and Q may be favorable candidates for novel stent coatings, potentially reducing the risk of late thrombosis associated with drug-eluting stents.
Authors:
James J Kleinedler; John D Foley; Elysse A Orchard; Tammy R Dugas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-17
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  159     ISSN:  1873-4995     ISO Abbreviation:  J Control Release     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-08-07     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71103, United States.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty
Animals
Antimitotic Agents / administration & dosage*
Cell Proliferation / drug effects
Constriction, Pathologic / drug therapy
Drug-Eluting Stents*
Endothelium, Vascular / cytology,  drug effects*
Female
Hyperplasia / drug therapy,  pathology
Male
Nanocomposites
Neointima / drug therapy,  pathology
Quercetin / administration & dosage*
Rats
Rats, Sprague-Dawley
Stilbenes / administration & dosage*
Chemical
Reg. No./Substance:
0/Antimitotic Agents; 0/Stilbenes; 117-39-5/Quercetin; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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