Document Detail

Novel multilayer Ti foam with cortical bone strength and cytocompatibility.
MedLine Citation:
PMID:  23201016     Owner:  NLM     Status:  Publisher    
The major required functions for load-bearing orthopaedic implants are load-bearing and mechanical or biological fixation with the surrounding bone. Porous materials with appropriate mechanical properties and adequate pore structure for fixation are promising load-bearing implant material candidates. In our preceding work, we developed a novel titanium (Ti) foam sheet with 1-2 mm thickness by an original slurry foaming method. In the present work, we developed novel Ti foam with mechanical properties compatible with cortical bone and biological fixation capabilities by layer-by-layer stacking of different foam sheets having volumetric porosities of 80% and 17%. The resulting multilayer Ti foam exhibited a Young's modulus of 11-12 GPa and yield strength of 150-240 MPa in compression tests. In vitro cell culture on the sample revealed good cell penetration in the higher porosity foam (80% volumetric porosity) which reaches to 1.2 mm for 21 d of incubation. Cell penetration into the high porosity layers of multilayer sample was good and not influenced by the lower porosity layers. Calcification is also observed in the high porosity foam suggesting that our Ti foam does not inhibit bone formation. Contradictory requirements for high volumetric porosity and high strength were attained by role-sharing between the foam sheets of different porosities. The unique characteristics of the present multilayer Ti foam make them attractive for application in the field of orthopaedics.
Komei Kato; Shojiro Ochiai; Akiko Yamamoto; Yuzo Daigo; Keiichi Honma; Suguru Matano; Kenichi Omori
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Mitsubishi Material Corp. 1-297 Kitabukuro-cho, Omiya-ku, Saitama, 330-8508 Japan. Electronic address:
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