| Novel molecular targets for the prevention of fetal alcohol syndrome. | |
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MedLine Citation:
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PMID: 18221215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol abuse produces damaging effects on the CNS that leads to several types of disorders. When consumed during pregnancy, alcohol may cause craniofacial malformations, growth retardation and brain damage in offspring. These symptoms are grouped by the term fetal alcohol syndrome (FAS). FAS is the most common cause of non-genetic mental retardation in the western world. Substantial efforts to elucidate the molecular basis of these impairments are currently in progress. Whereas FAS is totally preventable by avoiding alcohol intake during pregnancy, efficient therapies to prevent or mitigate the effects of prenatal alcohol exposure are still not available but many pharmacological treatments have been developed to avoid alcohol intake and dependence in adults. The present article reviews the most relevant mechanisms of alcohol injury in developing brain and the strategies and patents that are currently available and in progress to prevent therapy for FAS. |
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Authors:
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Susana E Martínez; Gustavo Egea |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Recent patents on CNS drug discovery Volume: 2 ISSN: 1574-8898 ISO Abbreviation: Recent Pat CNS Drug Discov Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-02-14 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 101265656 Medline TA: Recent Pat CNS Drug Discov Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 23-35 Citation Subset: IM |
Affiliation:
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Departament de Biologia Cellular i Anatomia Patològica, Facultat de Medicina, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Antioxidants / therapeutic use Brain / pathology Female Fetal Alcohol Syndrome / pathology, prevention & control* Humans Neuroprotective Agents / therapeutic use Patents as Topic Pregnancy Risk Factors Vitamins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Neuroprotective Agents; 0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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