Document Detail

Novel mix-family homeobox genes in zebrafish and their differential regulation.
MedLine Citation:
PMID:  10814508     Owner:  NLM     Status:  MEDLINE    
We report the isolation of two novel zebrafish mix-type homeobox genes, mtx1 and mtx2. The homeodomains of both Mtx1 and Mtx2 exhibited a 50% amino acid identity to other Mix-family protein homeodomains. mtx1 was expressed throughout the yolk syncytial layer (YSL), an extraembryonic structure in teleosts, from the late-blastula to the mid-gastrula period. mtx2 was first expressed in the dorsal blastomeres soon after the mid-blastula transition, and slightly later in the entire blastoderm margin. After the late blastula period, mtx2 transcripts were detected in the YSL, and they were restricted to the dorsal YSL by the early gastrula period. The expression of mtx2 was dependent on Wnt signals but not on Nodal signals. mtx1 expression was not regulated by either Wnt or Nodal signals. This is in complete contrast to the Nodal signal-dependent expression of mixer. These results indicate the complexity of the regulation of mix-type homeobox genes.
T Hirata; Y Yamanaka; S L Ryu; T Shimizu; T Yabe; M Hibi; T Hirano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  271     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  603-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Division of Molecular Oncology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan.
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MeSH Terms
Amino Acid Sequence
Chromosome Mapping
Cloning, Molecular
Embryo, Nonmammalian / metabolism
Gene Expression Regulation, Developmental / genetics*
Homeodomain Proteins / chemistry,  genetics*
In Situ Hybridization
Molecular Sequence Data
Nodal Protein
Proto-Oncogene Proteins / genetics
RNA, Messenger / metabolism
Sequence Homology, Amino Acid
Signal Transduction
Transforming Growth Factor beta / genetics,  metabolism
Wnt Proteins
Zebrafish / embryology*
Zebrafish Proteins*
Reg. No./Substance:
0/Homeodomain Proteins; 0/Nodal Protein; 0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/Transforming Growth Factor beta; 0/Wnt Proteins; 0/Zebrafish Proteins; 0/mxtx1 protein, zebrafish; 0/mxtx2 protein, zebrafish; 0/wnt8b protein, zebrafish

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