Document Detail


Novel method for non-invasive induction of a middle-ear biofilm in the rat.
MedLine Citation:
PMID:  21211589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Otitis media and other middle ear diseases are extremely common among all children worldwide. Chronic otitis media is strongly associated with the presence of a bacterial middle ear biofilm, which if left untreated, may result in hearing loss or delays in the development of speech and language. Many animal models and methods used to study the progression of various middle ear diseases exist. However, there are no reported approaches to biofilm induction in which this infectious process can be investigated. Here we report a unique, non-invasive method of biofilm induction in the rat through repeated bacterial inoculations and pressure changes within the ear.
Authors:
Eric J Chaney; Cac T Nguyen; Stephen A Boppart
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Publication Detail:
Type:  Journal Article     Date:  2011-01-04
Journal Detail:
Title:  Vaccine     Volume:  29     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-04-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1628-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Animals
Bacterial Adhesion
Biofilms / growth & development*
Disease Models, Animal*
Ear, Middle / microbiology*
Female
Otitis Media / microbiology*
Pressure
Rats
Rats, Sprague-Dawley
Streptococcus pneumoniae / growth & development,  pathogenicity
Grant Support
ID/Acronym/Agency:
R01 EB005221/EB/NIBIB NIH HHS; R01 EB005221-04/EB/NIBIB NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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