Document Detail


Novel metal-based anticancer drugs: a new challenge in drug delivery.
MedLine Citation:
PMID:  22609113     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Since the serependitous discovery of the cisplatin antiproliferative activity, many efforts have focused on the design of potent metal-based drugs for oncology therapies. A large number of these complexes have been evaluated in vitro and in vivo and some have reached clinical trials. However, while metallodrug chemistry has developed to an advanced level, these emerging therapeutics have encountered new hurdles including poor water solubility and pharmacological deficiencies. Today, solutions to overcome these issues do not lie in synthesizing new anticancer drugs but in finding suitable drug delivery strategies. Over the past decades, various delivery systems have been developed including prodrug, ligand design and nanocarriers aimed at enhancing the performance profile of these novel metallodrugs.
Authors:
Anne-Laure Lainé; Catherine Passirani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  -     ISSN:  1471-4973     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
LUNAM Université - Ingénierie de la vectorisation particulaire in Macro et nanomédecines biomimétiques, F-49933 Angers, France; Inserm - U1066 IBS-CHU, F-49933 Angers, France.
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