Document Detail


Novel mechanisms for the control of renin synthesis and release.
MedLine Citation:
PMID:  20425155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Renin is the key regulated step in the enzymatic cascade that leads to angiotensin generation and the control of blood pressure and fluid/electrolyte homeostasis. In the adult unstressed animal, renin is synthesized and released by renal juxtaglomerular cells. However, when homeostasis is threatened, the number of cells that express and release renin increases and extends beyond the juxtaglomerular area; the result is an increase in circulating renin and the reestablishment of homeostasis. The increase in the number of renin cells, a process termed recruitment, is achieved by dedifferentiation and re-expression of renin in cells derived from the renin lineage. The mechanisms that regulate the related processes of reacquisition of the renin phenotype, renin synthesis, and renin release are beginning to be understood. Numerous studies point to cAMP as a central common factor for the regulation of renin phenotype. In addition, we are seeing the emergence of gap junctions and microRNAs as new and promising avenues for a more complete understanding of the complex regulation of the renin cell.
Authors:
Maria Luisa S Sequeira Lopez; R Ariel Gomez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  12     ISSN:  1534-3111     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-29     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Calcium / physiology
Cyclic AMP / physiology
Gap Junctions / physiology
Histone Acetyltransferases / physiology
Homeostasis / physiology
Humans
Juxtaglomerular Apparatus / physiology
Kidney / physiology
MicroRNAs / physiology
Neuronal Plasticity / physiology
RNA Processing, Post-Transcriptional / physiology
Receptors, CCR / physiology
Recruitment, Neurophysiological / physiology
Renin / biosynthesis*,  metabolism
Transcriptional Activation / physiology
Grant Support
ID/Acronym/Agency:
DK75481/DK/NIDDK NIH HHS; HL066242/HL/NHLBI NIH HHS; K08 DK075481/DK/NIDDK NIH HHS; K08 DK075481-04/DK/NIDDK NIH HHS; R37 HL066242/HL/NHLBI NIH HHS; R37 HL066242-08/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/Receptors, CCR; E0399OZS9N/Cyclic AMP; EC 2.3.1.48/Histone Acetyltransferases; EC 3.4.23.15/Renin; SY7Q814VUP/Calcium
Comments/Corrections

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