| Novel mechanisms for the control of renin synthesis and release. | |
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MedLine Citation:
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PMID: 20425155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renin is the key regulated step in the enzymatic cascade that leads to angiotensin generation and the control of blood pressure and fluid/electrolyte homeostasis. In the adult unstressed animal, renin is synthesized and released by renal juxtaglomerular cells. However, when homeostasis is threatened, the number of cells that express and release renin increases and extends beyond the juxtaglomerular area; the result is an increase in circulating renin and the reestablishment of homeostasis. The increase in the number of renin cells, a process termed recruitment, is achieved by dedifferentiation and re-expression of renin in cells derived from the renin lineage. The mechanisms that regulate the related processes of reacquisition of the renin phenotype, renin synthesis, and renin release are beginning to be understood. Numerous studies point to cAMP as a central common factor for the regulation of renin phenotype. In addition, we are seeing the emergence of gap junctions and microRNAs as new and promising avenues for a more complete understanding of the complex regulation of the renin cell. |
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Authors:
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Maria Luisa S Sequeira Lopez; R Ariel Gomez |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 12 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-29 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 26-32 Citation Subset: IM |
Affiliation:
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University of Virginia School of Medicine, 409 Lane Road, Charlottesville, VA 22908, USA. msl7u@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Calcium / physiology Cyclic AMP / physiology Gap Junctions / physiology Histone Acetyltransferases / physiology Homeostasis / physiology Humans Juxtaglomerular Apparatus / physiology Kidney / physiology MicroRNAs / physiology Neuronal Plasticity / physiology RNA Processing, Post-Transcriptional / physiology Receptors, CCR / physiology Recruitment, Neurophysiological / physiology Renin / biosynthesis*, metabolism Transcriptional Activation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK75481/DK/NIDDK NIH HHS; HL066242/HL/NHLBI NIH HHS; K08 DK075481-04/DK/NIDDK NIH HHS; R37 HL066242-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs; 0/Receptors, CCR; 60-92-4/Cyclic AMP; 7440-70-2/Calcium; EC 2.3.1.48/Histone Acetyltransferases; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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