| Chapter 11--novel mechanism for hyperreflexia and spasticity. | |
| | |
MedLine Citation:
|
PMID: 21333809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We established that hyperreflexia is delayed after spinal transection in the adult rat and that passive exercise could normalize low frequency-dependent depression of the H-reflex. We were also able to show that such passive exercise will normalize hyperreflexia in patients with spinal cord injury (SCI). Recent results demonstrate that spinal transection results in changes in the neuronal gap junction protein connexin 36 below the level of the lesion. Moreover, a drug known to increase electrical coupling was found to normalize hyperreflexia in the absence of passive exercise, suggesting that changes in electrical coupling may be involved in hyperreflexia. We also present results showing that a measure of spasticity, the stretch reflex, is rendered abnormal by transection and normalized by the same drug. These data suggest that electrical coupling may be dysregulated in SCI, leading to some of the symptoms observed. A novel therapy for hyperreflexia and spasticity may require modulation of electrical coupling. |
| | |
Authors:
|
C Yates; K Garrison; N B Reese; A Charlesworth; E Garcia-Rill |
Related Documents
:
|
11011909 - Effects of sibutramine plus orlistat in obese women following 1 year of treatment by si... 8486029 - Effects of obesity on respiratory resistance. 9306879 - The prediction of total body water from bioelectrical impedance in patients with anorex... 18054709 - Influence of the trp64arg polymorphism in the beta 3 adrenoreceptor gene on insulin res... 8772219 - Hes 200/0.5 is not hes 200/0.5. influence of the c2/c6 hydroxyethylation ratio of hydro... 3875899 - Studies on the profibrinolytic actions of heparin and its fractions. 12463399 - Oxidant injury, nitric oxide and pulmonary vascular function: implications for the exer... 6777109 - Fat metabolism in heavy exercise. 12971129 - An evaluation of affect and binge eating. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Progress in brain research Volume: 188 ISSN: 1875-7855 ISO Abbreviation: Prog. Brain Res. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-02-21 Completed Date: 2011-06-23 Revised Date: 2013-05-26 |
Medline Journal Info:
|
Nlm Unique ID: 0376441 Medline TA: Prog Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 167-80 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
|
Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals H-Reflex / physiology Humans Movement / physiology Muscle Spasticity / physiopathology* Periodicity Reflex, Abnormal / physiology* Reflex, Stretch / physiology Spinal Cord Injuries / pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
NS062363/NS/NINDS NIH HHS; P20 GM103425/GM/NIGMS NIH HHS; P20 RR020146/RR/NCRR NIH HHS; P20 RR20146/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A hierarchical perspective on rhythm generation for locomotor control.
Next Document: Modulation of rhythmic movement Control of coordination.