Document Detail


Chapter 11--novel mechanism for hyperreflexia and spasticity.
MedLine Citation:
PMID:  21333809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We established that hyperreflexia is delayed after spinal transection in the adult rat and that passive exercise could normalize low frequency-dependent depression of the H-reflex. We were also able to show that such passive exercise will normalize hyperreflexia in patients with spinal cord injury (SCI). Recent results demonstrate that spinal transection results in changes in the neuronal gap junction protein connexin 36 below the level of the lesion. Moreover, a drug known to increase electrical coupling was found to normalize hyperreflexia in the absence of passive exercise, suggesting that changes in electrical coupling may be involved in hyperreflexia. We also present results showing that a measure of spasticity, the stretch reflex, is rendered abnormal by transection and normalized by the same drug. These data suggest that electrical coupling may be dysregulated in SCI, leading to some of the symptoms observed. A novel therapy for hyperreflexia and spasticity may require modulation of electrical coupling.
Authors:
C Yates; K Garrison; N B Reese; A Charlesworth; E Garcia-Rill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Progress in brain research     Volume:  188     ISSN:  1875-7855     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-06-23     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  167-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
H-Reflex / physiology
Humans
Movement / physiology
Muscle Spasticity / physiopathology*
Periodicity
Reflex, Abnormal / physiology*
Reflex, Stretch / physiology
Spinal Cord Injuries / pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
NS062363/NS/NINDS NIH HHS; P20 GM103425/GM/NIGMS NIH HHS; P20 RR020146/RR/NCRR NIH HHS; P20 RR20146/RR/NCRR NIH HHS
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