Document Detail


Novel integrative approaches to the identification of candidate genes in hypertension.
MedLine Citation:
PMID:  16344362     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension, diabetes, and obesity are common diseases that are genetically expressed as complex traits. The clinical expression of these diseases, which run in families but have no clear pattern of inheritance, has been attributed to the interaction between multiple genes and the environment. Identifying the underlying genes, a crucial step in understanding the molecular pathogenesis of complex diseases, has had limited success so far, stressing the need for novel strategies to move this process forward. Innovative integrative genetic-genomic approaches have been proposed recently for the identification of new high-priority candidate genes. These strategies, which combine expression profiling with genetic linkage in different ways, may represent a breakthrough in the search for the genes involved in complex diseases.
Authors:
Norbert Hubner; Chana Yagil; Yoram Yagil
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-12-12
Journal Detail:
Title:  Hypertension     Volume:  47     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Profiling*
Genetic Techniques / trends*
Humans
Hypertension / genetics*
Linkage (Genetics)*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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