Document Detail


Novel insights into the role of S100A8/A9 in skin biology.
MedLine Citation:
PMID:  22882537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
S100A8 and S100A9 belong to the damage-associated molecular pattern molecules. They are upregulated in a number of inflammatory skin disorders. Owing to their abundance in myeloid cells, the main function of S100A8/A9 has been attributed to their role in inflammatory cells. However, it is becoming increasingly clear that they also exert important roles in epithelial cells. In this review, we discuss the context-dependent function of S100A8/A9 in epithelial cells and their impact on wound healing, psoriasis and other skin diseases.
Authors:
Claus Kerkhoff; Andreas Voss; Thomas E Scholzen; Michelle M Averill; Kurt S Zänker; Karin E Bornfeldt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-09
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-03-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  822-6     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, AG EXIM, Rostock, Germany. kerkhoc@uni-muenster.de
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MeSH Terms
Descriptor/Qualifier:
Calgranulin A / physiology*
Calgranulin B / physiology*
Epithelial Cells / physiology*
Humans
Psoriasis / physiopathology
Skin Diseases / physiopathology
Skin Physiological Phenomena*
Wound Healing / physiology
Grant Support
ID/Acronym/Agency:
HL062887/HL/NHLBI NIH HHS; HL092969/HL/NHLBI NIH HHS; HL097365/HL/NHLBI NIH HHS; P01 HL092969/HL/NHLBI NIH HHS; R01 HL062887/HL/NHLBI NIH HHS; R01 HL097365/HL/NHLBI NIH HHS; T32 HL07828/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Calgranulin A; 0/Calgranulin B
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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