Document Detail

Novel insights into the mechanisms of pregnancy establishment: regulation of prostaglandin synthesis and signaling in the pig.
MedLine Citation:
PMID:  21677026     Owner:  NLM     Status:  Publisher    
Ovarian progesterone induces essential changes leading to a temporary state of uterine receptivity for conceptus implantation. Estrogens secreted by the porcine conceptus on day 11 and 12 of pregnancy, provide the initial signal for maternal recognition of pregnancy and maintenance of a functional corpus luteum (CL) for continued production of progesterone. As prostaglandins F2alpha (PGF2alpha) and E2 (PGE2) exert opposite action on the CL, a tight control over their synthesis and secretion is critical either for the initiation of luteolysis, or maintenance of pregnancy. One of the supportive mechanisms by which conceptus inhibits luteolysis is changing PG synthesis in favor of luteoprotective PGE2. Conceptus PGE2 could be amplified by PGE2 feedback loop in the endometrium. In pigs, as in other species, implantation and establishment of pregnancy is associated with up-regulation of expression of proinflammatory factors, which include cytokines, growth factors and lipid mediators. The conceptus produces inflammatory mediators: interferons IFNG and IFND, interleukins IL1B, IL6, and PGs, that probably activate inflammatory pathways in the endometrium. The endometrium responds to these embryonic signals by enhancing further progesterone-induced uterine receptivity. Understanding the mechanisms of pregnancy establishment is required for translational research to increase reproductive efficiencies and fertility in humans and animals.
Agnieszka Waclawik
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-15
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
A Waclawik, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, 10-747, Poland.
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