Document Detail

Novel insight into the function and regulation of alphaN-catenin by Snail2 during chick neural crest cell migration.
MedLine Citation:
PMID:  20542025     Owner:  NLM     Status:  MEDLINE    
The neural crest is a transient population of migratory cells that differentiates to form a variety of cell types in the vertebrate embryo, including melanocytes, the craniofacial skeleton, and portions of the peripheral nervous system. These cells initially exist as adherent epithelial cells in the dorsal aspect of the neural tube and only later become migratory after an epithelial-to-mesenchymal transition (EMT). Snail2 plays a critical role in mediating chick neural crest cell EMT and migration due to its expression by both premigratory and migratory cranial neural crest cells and its ability to down-regulate intercellular junctions components. In an attempt to delineate the role of cellular junction components in the neural crest, we have identified the adherens junction molecule neural alpha-catenin (alphaN-catenin) as a Snail2 target gene whose repression is critical for chick neural crest cell migration. Knock-down and overexpression of alphaN-catenin enhances and inhibits neural crest cell migration, respectively. Furthermore, our results reveal that alphaN-catenin regulates the appropriate movement of neural crest cells away from the neural tube into the embryo. Collectively, our data point to a novel function of an adherens junction protein in facilitating the proper migration of neural crest cells during the development of the vertebrate embryo.
S Jhingory; C-Y Wu; L A Taneyhill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-11
Journal Detail:
Title:  Developmental biology     Volume:  344     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-08-30     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  896-910     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Catenins / genetics,  metabolism,  physiology
Cell Differentiation / genetics,  physiology
Cell Movement / genetics,  physiology*
Chick Embryo
Embryo, Nonmammalian
Neural Crest / metabolism*,  physiology*
Neural Tube
Neurons / metabolism,  physiology
alpha Catenin / genetics,  metabolism,  physiology
Grant Support
R00 HD055034/HD/NICHD NIH HHS; R00 HD055034/HD/NICHD NIH HHS; R00 HD055034-02/HD/NICHD NIH HHS; R00 HD055034-03/HD/NICHD NIH HHS; R00 HD055034-03S2/HD/NICHD NIH HHS; R00 HD055034-04/HD/NICHD NIH HHS
Reg. No./Substance:
0/Catenins; 0/alpha Catenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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