| Novel index for invasively assessing the coronary microcirculation. | |
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MedLine Citation:
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PMID: 12821539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A relatively simple, invasive method for quantitatively assessing the status of the coronary microcirculation independent of the epicardial artery is lacking. METHODS AND RESULTS: By using a coronary pressure wire and modified software, it is possible to calculate the mean transit time of room-temperature saline injected down a coronary artery. The inverse of the hyperemic mean transit time has been shown to correlate with absolute flow. We hypothesize that distal coronary pressure divided by the inverse of the hyperemic mean transit time provides an index of microcirculatory resistance (IMR) that will correlate with true microcirculatory resistance (TMR), defined as the distal left anterior descending (LAD) pressure divided by hyperemic flow, measured with an external ultrasonic flow probe. A total of 61 measurements were made in 9 Yorkshire swine at baseline and after disruption of the coronary microcirculation, both with and without an epicardial LAD stenosis. The mean IMR (16.9+/-6.5 U to 25.9+/-14.4 U, P=0.002) and TMR (0.51+/-0.14 to 0.79+/-0.32 mm Hg x mL(-1) x min(-1), P=0.0001), as well as the % change in IMR (147+/-66%) and TMR (159+/-105%, P=NS versus IMR % change), increased significantly and to a similar degree after disruption of the microcirculation. These changes were independent of the status of the epicardial artery. There was a significant correlation between mean IMR and TMR values, as well as between the % change in IMR and % change in TMR. CONCLUSIONS: Measuring IMR may provide a simple, quantitative, invasive assessment of the coronary microcirculation. |
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Authors:
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William F Fearon; Leora B Balsam; H M Omar Farouque; Anthony D Caffarelli; Robert C Robbins; Peter J Fitzgerald; Paul G Yock; Alan C Yeung |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2003-06-23 |
Journal Detail:
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Title: Circulation Volume: 107 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-01 Completed Date: 2003-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 3129-32 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA. wfearon@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Pressure Coronary Circulation / physiology* Coronary Stenosis / diagnosis*, ultrasonography Coronary Vessels / physiology, physiopathology Diagnostic Techniques, Cardiovascular* Linear Models Microcirculation / physiology*, ultrasonography Predictive Value of Tests Reproducibility of Results Swine Ultrasonography, Interventional Vascular Resistance / physiology* |
| Comments/Corrections | |
Erratum In:
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Circulation. 2003 Dec 23;108(25):3165 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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