Document Detail


Novel t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2) in acute megakaryoblastic leukemia AML-M7 subtype in an adult patient.
MedLine Citation:
PMID:  19665073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The strong association of diagnostic karyotype with clinical outcome has made cytogenetics one of the most valuable diagnostic and prognostic tools for acute myeloid leukemia (AML). The subtype M7 is a rare disease of the megakaryoblastic lineage and is mostly associated with complex abnormal karyotype. We describe the clinical, morphologic, immunophenotypic, and cytogenetic findings in the case of a 39-year-old man with acute megakaryoblastic leukemia (AML-M7). Cytogenetic analysis revealed two translocations, t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2), at presentation; to our knowledge, this combination is a novel finding for acute megakaryoblastic leukemia. The patient responded to induction therapy, achieving complete remission after 9 days of therapy.
Authors:
Firoz Ahmad; Rupa Dalvi; Bibhu Ranjan Das; Swarna Mandava
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  193     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  IM    
Affiliation:
Research and Development, Super Religare Laboratories, Mumbai 400093, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromosomes, Human*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Megakaryoblastic, Acute / genetics*
Male
Translocation, Genetic*

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