| Novel gel formulations with catanionic aggregates enable prolonged drug release and reduced skin permeation. | |
| | |
MedLine Citation:
|
PMID: 21899541 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objectives The aim of this study was to investigate skin permeation rates of a drug substance when applied in novel gel formulations with catanionic aggregates. Methods Reference gel without catanionic aggregates was compared with formulations with catanionic aggregates composed of tetracaine and either sodium dodecyl sulphate (SDS) or capric acid. Carbomer and SoftCAT were used to compare the effect of different gel types to elucidate if physically cross-linked, 'self-destructing' systems had benefits compared with classical, covalently cross-linked, gels. Key findings The rheological investigation showed that the interactions between the SoftCAT polymer and tetracaine/SDS aggregates were stronger than when the tetracaine/capric acid aggregates were used. The skin permeation was measured ex vivo in horizontal Ussing chambers and the permeation of tetracaine was significantly lower when formulations with tetracaine/SDS aggregates were applied (P < 0.001), but not statistically different from the reference when capric acid was used. Conclusions No morphological differences could be distinguished between the skin samples exposed to the different formulations or the reference. Skin permeation was compared with silicone sheet permeation and the results indicated that silicone sheets could be used as a model of skin when using these formulations. |
| | |
Authors:
|
Noel Dew; Katarina Edsman; Erik Björk |
Publication Detail:
|
Type: Journal Article Date: 2011-08-16 |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 63 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-09-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 1265-73 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. |
Affiliation:
|
Uppsala University, Department of Pharmacy, Uppsala, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing...
Next Document: In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation.