| Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. | |
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MedLine Citation:
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PMID: 21697096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions. |
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Authors:
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Mo Xu; Hyoe-Jin Joo; Young-Ki Paik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-06-22 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 286 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-11 Completed Date: 2012-05-11 Revised Date: 2012-09-26 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 28111-8 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biomedical Science, World Class University Program, College of Life Science and Biotechnology, Yonsei Proteome Research Center, Yonsei University, Seoul 120-749, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Active Transport, Cell Nucleus
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physiology Animals Caenorhabditis elegans / genetics, metabolism* Caenorhabditis elegans Proteins / genetics, metabolism* Carrier Proteins / genetics, metabolism* Cell Nucleus / genetics, metabolism* Energy Metabolism / physiology Fatty Acid-Binding Proteins / genetics, metabolism* Lipid Metabolism / physiology* Protein Binding Receptors, Cytoplasmic and Nuclear / genetics, metabolism Stearic Acids / metabolism* Transcription, Genetic / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Carrier Proteins; 0/Fatty Acid-Binding Proteins; 0/NHR-49 protein, C elegans; 0/Receptors, Cytoplasmic and Nuclear; 0/Stearic Acids; 0/lipid-binding protein 5, C elegans; 57-11-4/stearic acid |
| Comments/Corrections | |
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