Document Detail


Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism.
MedLine Citation:
PMID:  21697096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lipid-binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions.
Authors:
Mo Xu; Hyoe-Jin Joo; Young-Ki Paik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-22
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  286     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-11     Completed Date:  2012-05-11     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28111-8     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biomedical Science, World Class University Program, College of Life Science and Biotechnology, Yonsei Proteome Research Center, Yonsei University, Seoul 120-749, Korea.
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MeSH Terms
Descriptor/Qualifier:
Active Transport, Cell Nucleus / physiology
Animals
Caenorhabditis elegans / genetics,  metabolism*
Caenorhabditis elegans Proteins / genetics,  metabolism*
Carrier Proteins / genetics,  metabolism*
Cell Nucleus / genetics,  metabolism*
Energy Metabolism / physiology
Fatty Acid-Binding Proteins / genetics,  metabolism*
Lipid Metabolism / physiology*
Protein Binding
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism
Stearic Acids / metabolism*
Transcription, Genetic / physiology*
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Carrier Proteins; 0/Fatty Acid-Binding Proteins; 0/NHR-49 protein, C elegans; 0/Receptors, Cytoplasmic and Nuclear; 0/Stearic Acids; 0/lipid-binding protein 5, C elegans; 4ELV7Z65AP/stearic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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