| Novel functions of LBP-5 in Caenorhabditis elegans fat metabolism. | |
| | |
MedLine Citation:
|
PMID: 21697096 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The lipid binding protein (LBP) family is conserved from Caenorhabditis elegans to mammals and essential for fatty acid homeostasis. RNAi-mediated knockdown of nine C. elegans lbp family members revealed that lbp-5 regulates fat accumulation. C. elegans LBP-5 bound directly to various fatty acids with varying affinities. Lbp-5 expression in nhr-49(nr2041) worms was much lower than in N2 worms. Nhr-49 transcriptional activity also decreased with lbp-5 deletion, suggesting that they may work together as functional partners in fat metabolism. In support of this notion, LBP-5 translocated into nuclei, where it appeared to influence C. elegans NHR-49 target genes involved in energy metabolism. Interestingly, LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes. Thus, this knowledge could help identify therapeutic targets to treat obesity and diseases associated with nematode-host interactions. |
| | |
Authors:
|
Mo Xu; Hyoe-Jin Joo; Young-Ki Paik |
Related Documents
:
|
10748326 - Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxici... 16332916 - Efficacy of orally administered amphipathic polyaminocarboxylic acid chelators for the ... 11225696 - Comparative study on sorption/desorption of radioeuropium on alumina, bentonite and red... 15122306 - Asbestos-derived reactive oxygen species activate tgf-beta1. 15844326 - Recognition of bile acids at cyclodextrin-modified gold electrodes. 1596496 - The metabolic utilization of amino acids: potentials of 14co2 breath test measurements. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
|
Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Yonsei University, Korea, Republic of. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
Next Document: Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme,...