| Novel functional biodegradable polymer: synthesis and anticoagulant activity of poly(gamma-glutamic acid)sulfonate (gamma-PGA-sulfonate). | |
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MedLine Citation:
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PMID: 11792175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Poly(glutamic acid) (gamma-PGA), which is produced by Bacillus subtilis, was sulfonated using 2-aminoethane-1-sulfonic acid (taurine) in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (WSC) to give sulfonated gamma-PGA (gamma-PGA-sulfonate). From (1)H NMR spectroscopy and IR spectroscopy, it was confirmed that taurine was introduced to the side chain of gamma-PGA via an amide linkage. By altering the synthetic conditions, it was possible to control the content of sulfonate in gamma-PGA-sulfonate. Anticoagulant activity was investigated in order to evaluate the biological activity of gamma-PGA-sulfonate by the Lee-White test. The clotting time was prolonged when the concentration of gamma-PGA-sulfonate on the degree of sulfonation was increased. It becomes clear that gamma-PGA-sulfonate is potentially useful for various medical applications, such as drug delivery, tissue engineering, and medical materials. |
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Authors:
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Michiya Matsusaki; Takeshi Serizawa; Akio Kishida; Takeshi Endo; Mitsuru Akashi |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 13 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-01-16 Completed Date: 2002-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, I-21-40 Korimoto, Kagoshima 890-0065, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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chemical synthesis*,
pharmacology* Bacillus subtilis / metabolism Esters / chemistry Humans Hydrolysis Molecular Weight Polyglutamic Acid / analogs & derivatives, chemical synthesis*, pharmacology* Solubility Solutions Taurine / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Esters; 0/Solutions; 0/poly(glutamic acid)sulfonate; 107-35-7/Taurine; 25513-46-6/Polyglutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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