| Novel findings in drug-induced dendritic cell tolerogenicity. | |
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MedLine Citation:
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PMID: 21073328 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Dendritic cells (DCs) constitute a unique set of antigen-presenting cells (APCs), equipped with the potential to initiate strong immune responses as well as to critically regulate immunity. Tolerogenic or "alternatively activated" DCs show remarkable properties in regulating immune responses both in vitro and in vivo. Furthermore, tolerogenic DCs are now beginning to be tested in clinical studies. Use of pharmacological agents to induce maturation-resistant tolerogenic DCs is a popular approach. In this review, we will discuss already recognized, as well as recently discovered, potential pharmacological agents, their mechanism of action, and the way in which they induce tolerance in DCs. |
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Authors:
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Urban Svajger; Nataša Obermajer; Matjaž Jeras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International reviews of immunology Volume: 29 ISSN: 1563-5244 ISO Abbreviation: Int. Rev. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712260 Medline TA: Int Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 574-607 Citation Subset: IM |
Affiliation:
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Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, and Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. svajgerurban@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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