| Novel female sex-dependent actions of oestrogen in the intestine. | |
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MedLine Citation:
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PMID: 19723780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intestine is an oestrogen responsive organ and circulatory oestrogens suppress Cl(-) secretion across the epithelium of the colon to promote fluid retention at the luteal stage of the menstrual cycle. Ion transporters in the colon which are involved in Cl(-) secretion show differential expression between males and females as do the signalling protein kinase intermediates involved in acutely regulating these transporters. Work from our laboratory has identified the KCNQ1/KCNE3 channel as one of the principal targets for oestrogen-induced signalling cascades in the distal colon. Through inhibition of the KCNQ1 channel, basolateral K(+) recycling is decreased so reducing the favourable electrochemical gradient for Cl(-) extrusion at the apical membrane. The actions of oestrogen on non-reproductive tissues such as the colon, kidney, lung and sweat gland will affect whole body electrolyte and fluid homeostasis and also have consequences for reproductive potential. |
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Authors:
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Fiona O'Mahony; Warren Thomas; Brian J Harvey |
Publication Detail:
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Type: Journal Article; Review Date: 2009-09-01 |
Journal Detail:
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Title: The Journal of physiology Volume: 587 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2010-01-06 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 5039-44 Citation Subset: IM |
Affiliation:
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Royal College of Surgeons in Ireland, Department of Molecular Medicine, Dublin 17, Ireland. fomahony@rcsi.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorine / metabolism* Estrogens / metabolism* Female Humans Intestines / physiology* Ion Channels / physiology* Menstrual Cycle / physiology* Potassium / metabolism* Sex Factors Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Ion Channels; 7440-09-7/Potassium; 7782-50-5/Chlorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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