Document Detail

Novel female sex-dependent actions of oestrogen in the intestine.
MedLine Citation:
PMID:  19723780     Owner:  NLM     Status:  MEDLINE    
The intestine is an oestrogen responsive organ and circulatory oestrogens suppress Cl(-) secretion across the epithelium of the colon to promote fluid retention at the luteal stage of the menstrual cycle. Ion transporters in the colon which are involved in Cl(-) secretion show differential expression between males and females as do the signalling protein kinase intermediates involved in acutely regulating these transporters. Work from our laboratory has identified the KCNQ1/KCNE3 channel as one of the principal targets for oestrogen-induced signalling cascades in the distal colon. Through inhibition of the KCNQ1 channel, basolateral K(+) recycling is decreased so reducing the favourable electrochemical gradient for Cl(-) extrusion at the apical membrane. The actions of oestrogen on non-reproductive tissues such as the colon, kidney, lung and sweat gland will affect whole body electrolyte and fluid homeostasis and also have consequences for reproductive potential.
Fiona O'Mahony; Warren Thomas; Brian J Harvey
Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-01
Journal Detail:
Title:  The Journal of physiology     Volume:  587     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-06     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5039-44     Citation Subset:  IM    
Royal College of Surgeons in Ireland, Department of Molecular Medicine, Dublin 17, Ireland.
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MeSH Terms
Chlorine / metabolism*
Estrogens / metabolism*
Intestines / physiology*
Ion Channels / physiology*
Menstrual Cycle / physiology*
Potassium / metabolism*
Sex Factors
Signal Transduction / physiology*
Reg. No./Substance:
0/Estrogens; 0/Ion Channels; 7440-09-7/Potassium; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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