Document Detail


Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
MedLine Citation:
PMID:  19243017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural crest (NC) cells are a multipotent, highly migratory cell population that generates most of the components of the peripheral nervous system (PNS), including the glial Schwann cells (SC) and boundary cap (BC) cells. These latter cells are located at the interface between the central nervous system and PNS, at the exit/entry points of ventral motor/dorsal sensory axons and give rise to all SC in the nerve roots and to a subset of nociceptive neurons and satellite cells in the dorsal root ganglia. In the present study we have compared BC cells with two closely related cell types, NC and Schwann cell precursors (SCpr), by RNA profiling. This led to the definition of a set of 10 genes that show specific expression in BC cells and/or in their derivatives along the nerve roots. Analysis of the expression of these genes during mouse development revealed novel features, of those most important are: (i) dorsal and ventral nerve root BC cell derivatives express different sets of genes, suggesting that they have distinct properties; (ii) these cells undergo major modifications in their gene expression pattern between embryonic days 14.5 and 17.5, possibly linked to the SCpr-immature Schwann cell transition; (iii) nerve roots SC differ from more distal SC not only in their origins and locations, but also in their gene expression patterns. In conclusion, the identification of these novel makers opens the way for a detailed characterization of BC cells in both mouse and man.
Authors:
Fanny Coulpier; Stéphane Le Crom; Géraldine S Maro; Jan Manent; Marco Giovannini; Zofia Maciorowski; Andreas Fischer; Manfred Gessler; Patrick Charnay; Piotr Topilko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Glia     Volume:  57     ISSN:  1098-1136     ISO Abbreviation:  Glia     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1450-7     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Affiliation:
INSERM, CNRS, IFR36, Plate-forme Transcriptome, 46 rue d'Ulm, 75230 Paris Cedex 05, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics,  metabolism
Biological Markers / metabolism
Early Growth Response Protein 2 / genetics,  metabolism
Gene Expression Regulation, Developmental*
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Transgenic
Neural Crest / embryology*,  physiology*
Oligonucleotide Array Sequence Analysis
RNA / metabolism
Receptors, Atrial Natriuretic Factor / genetics,  metabolism
Repressor Proteins / genetics,  metabolism
Reverse Transcriptase Polymerase Chain Reaction
Ribosomal Proteins / genetics,  metabolism
Schwann Cells / physiology
Spinal Nerve Roots / embryology,  physiology
Stem Cells / physiology
Chemical
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Biological Markers; 0/Early Growth Response Protein 2; 0/Hey2 protein, mouse; 0/Heyl protein, mouse; 0/Repressor Proteins; 0/Ribosomal Proteins; 63231-63-0/RNA; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor; EC 4.6.1.2/atrial natriuretic factor receptor C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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