Document Detail

Novel families of vacuolar amino acid transporters.
MedLine Citation:
PMID:  18459165     Owner:  NLM     Status:  MEDLINE    
Amino acids are compartmentalized in the vacuoles of microorganisms and plants. In Saccharomyces cerevisiae, basic amino acids accumulate preferentially into vacuoles but acidic amino acids are almost excluded from them. This indicates that selective machineries operate at the vacuolar membrane. The members of the amino acid/auxin permease family and the major facilitator superfamily involved in the vacuolar compartmentalization of amino acids have been recently identified in studies using S. cerevisiae. Homologous genes for these transporters are also found in plant and mammalian genomes. The physiological significance in response to nitrogen starvation can now be discussed.
Takayuki Sekito; Yuki Fujiki; Yoshinori Ohsumi; Yoshimi Kakinuma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  IUBMB life     Volume:  60     ISSN:  1521-6551     ISO Abbreviation:  IUBMB Life     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Copyright Information:
(c) 2008 IUBMB
Department of Applied Bioscience, Faculty of Agriculture, Tarumi 3-5-7, Ehime University, Matsuyama, Ehime, Japan.
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MeSH Terms
Amino Acid Transport Systems / genetics*
Amino Acids / metabolism*
Intracellular Membranes / metabolism
Multigene Family / genetics*
Saccharomyces cerevisiae / genetics,  metabolism*
Vacuoles / metabolism*
Reg. No./Substance:
0/Amino Acid Transport Systems; 0/Amino Acids

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