Document Detail

Novel evidence that nitric oxide of the medial septal area influences the salivary secretion induced by pilocarpine.
MedLine Citation:
PMID:  12150204     Owner:  NLM     Status:  MEDLINE    
Our studies have focused on the effect of injection of L-NAME and sodium nitroprussiate (SNP) on the salivary secretion, arterial blood pressure, sodium excretion and urinary volume induced by pilocarpine which was injected into the medial septal area (MSA). Rats were anesthetized with urethane (1.25 g/kg b. wt.) and a stainless steel cannula was implanted into their MSA. The amount of saliva secretion was studied over a five-minute period after injection of pilocarpine into MSA. Injection of pilocarpine (10, 20, 40, 80, 160 microg/microl) into MSA produced a dose-dependent increase in salivary secretion. L-NG-nitro arginine methyl-esther (L-NAME) (40 microg/microl), a nitric oxide (NO) synthase inhibitor, was injected into MSA prior to the injection of pilocarpine into MSA, producing an increase in salivary secretion due to the effect of pilocarpine. Sodium nitroprussiate (SNP) (30 microg/microl) was injected into MSA prior to the injection of pilocarpine into MSA attenuating the increase in salivary secretion induced by pilocarpine. Medial arterial pressure (MAP) increase after injections of pilocarpine into the MSA. L-NAME injected into the MSA prior to injection of pilocarpine into MSA increased the MAP. SNP injected into the MSA prior to pilocarpine attenuated the effect of pilocarpine on MAP. Pilocarpine (40 ug/ul) injected into the MAS induced an increase in sodium and urinary excretion. L-NAME injected prior to pilocarpine into the MSA increased the urinary sodium excretion and urinary volume induced by pilocarpine. SNP injected prior to pilocarpine into the MSA decreased the sodium excretion and urinary volume induced by pilocarpine. All these roles of pilocarpine depend on the release of nitric oxide into the MSA. We may also conclude that the MSA is involved with the cholinergic excitatory mechanism that induce salivary secretion, increase in MAP and increase in sodium excretion and urinary volume.
Wilson Abrão Saad; Ismael Francisco Motta Siqueira Guarda; Luiz Antonio de Arruda Camargo; Talmir Augusto Faria Brisola dos Santos; William Abrão Saad; Sylvio Simões; Renata Saad Guarda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  70     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2002-08-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2403-12     Citation Subset:  IM    
Department of Physiology and Pathology School of Dentistry, Paulista State University, UNESP Araraquara, SP Brazil.
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MeSH Terms
Blood Pressure / drug effects
Enzyme Inhibitors / pharmacology
Hemodynamics / drug effects
Kidney / drug effects
Muscarinic Agonists / administration & dosage,  pharmacology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors
Nitroprusside / pharmacology
Pilocarpine / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Salivation / drug effects*
Septum of Brain / physiology*
Sodium / blood,  urine
Urodynamics / drug effects
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Muscarinic Agonists; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 50903-99-6/NG-Nitroarginine Methyl Ester; 7440-23-5/Sodium; 92-13-7/Pilocarpine; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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