Document Detail

Novel evidence that beta adrenoceptors of the medial septal area regulate blood pressure and electrolyte balance.
MedLine Citation:
PMID:  7564908     Owner:  NLM     Status:  MEDLINE    
We investigated the participation of the beta-adrenoceptors of the septa area (SA) in sodium and potassium excretion and urine flow. The alterations in arterial pressure and some renal functions were also investigated. The injection of 2.10(-9) to 16.10(-9) M of isoproterenol, through a cannula permanently implanted into the SA produced a significant dose-dependent decrease in urinary Na+ and K+ excretion and urinary flow. Pretreatment with 16.10(-9) M butoxamine antagonized the effect of 4.10(-9) M isoproterenol but pretreatment with 16.10(-9) M practolol did not abolish the effect of isoproterenol. The beta 2-agonist terbutaline and salbutamol (4.10(-9) M when injected intraseptally also caused a decrease in urine flow and in renal Na+ and K+ excretion. After injection of isoproterenol or salbutamol (4.10(-9) M) into the SA, the arterial pressure, glomerular, filtration rate (GFR) and filtered Na+ were reduced while Na+ fractional reabsorption was increased. The results indicate that the beta 2-adrenoceptors of the SA play a role in the decrease of Na+, K+ and urine flow and this effect may be due to a drop in GFR and filtered Na+ and to the rise in tubular Na+ reabsorption.
W A Saad; J V Menani; L A Camargo; J A Antunes-Rodrigues; W A Saad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  57     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1995  
Date Detail:
Created Date:  1995-11-06     Completed Date:  1995-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1605-11     Citation Subset:  IM    
Department of Physiology, School of Dentistry, Paulista State University, Araraquara SP, Brazil.
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MeSH Terms
Blood Pressure / physiology*
Dose-Response Relationship, Drug
Isoproterenol / pharmacology
Potassium / urine
Rats, Inbred Strains
Receptors, Adrenergic, beta / drug effects*,  physiology*
Septum Pellucidum / physiology*
Sodium / urine
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 7440-09-7/Potassium; 7440-23-5/Sodium; 7683-59-2/Isoproterenol

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