Document Detail

Novel evaluation of nephrolithiasis complicated in gout: A cross-sectional study using helical computed tomography.
MedLine Citation:
PMID:  23159585     Owner:  NLM     Status:  Publisher    
PURPOSE: To clarify whether the clinical profiles of patients with a history of urolithiasis ("stone formers") truly reflect those of patients who currently have renal stones ("stone carriers"). MATERIALS AND METHODS: 463 gout patients were investigated by helical computed tomography (CT), urolithiasis history, and relevant clinical parameters. RESULTS: 1) Nephrolithiasis was observed in 157(34%) of the 463 on CT. However, only 75(16%) of the 463 had a urolithiasis history. 107(68%) of the 157 stone carriers did not have the urolithiasis history. 2) Serum urate(Sua) and serum creatinine (Scr) levels of the 157 was higher (p=0.017) and the estimated glomerular filtration rate (eGFR) and urinary pH of the 157 were lower than those of the 306 non-stone carriers (p=0.0096, p=0.0249, respectively). However, there were no significant differences in laboratory findings between 75 stone formers and 388 non-stone formers. 3) Sua and Scr were higher and eGFR and urine pH of bilateral stone carriers were lower than those of unilateral stone carriers.4)According to Houndfield units of densities in CT, a one-third of the calculi complicated in 31 recent gout patients was estimated as uric acid stone. CONCLUSIONS: The concept of "stone formers" may lead to underestimating the prevalence of urolithiasis. Our analysis of "stone carriers" found that a higher stone burden is associated with greater renal derangement as determined by Sua, Scr, eGFR and urine pH. To accurately clarify the correlation of gout and urolithiasis, it is advantageous to select stone carriers as subjects of study.
Toru Shimizu; Hitoshi Kitada; Masanori Umeyama; Hiroshi Hori; Noboru Takasaki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Chief, Gout Clinic in Dept. of Rheumatology, Midorigaoka Hospital, 3-13-1 Makami-cho, Takatsuki-shi, Osaka 569-1121, JAPAN. Electronic address:
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