Document Detail

Novel estimates of the exposure to flavouring substances.
MedLine Citation:
PMID:  15093267     Owner:  NLM     Status:  MEDLINE    
There are thousands of flavouring substances and hundreds of ways of consuming them. It is consequently impossible to carry out detailed analysis of the consumption patterns of each one, so as a result, it is necessary to find more practical and conservative methods for assessing exposure. Two studies have compared the suitability of one method: the maximised survey-derived daily intake (MSDI). In one of these studies, the MSDI-estimated intakes of nine flavouring substances and one spice oleoresin were compared with detailed dietary intakes calculated over a 14-day period using frequency of eating, portion sizes, levels of the flavouring substance and probability of presence in a particularly food item. In a second study, the MSDI-estimated intakes of 12 flavouring substances were compared with intakes calculated using a stochastic model. This model used real levels in over 40,000 flavour formulae used in 31 different categories of food for which the intakes of males in the 16-24 years age group had been surveyed. In both of these studies, the ability of the MSDI to accurately but conservatively estimate upper percentile intakes was demonstrated. This stochastic method offers an opportunity to test whether the MSDI can also be used to estimate the intakes of the volatile constituents that are common to a number of different botanically derived flavouring materials and food ingredients.
P Cadby
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology letters     Volume:  149     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Firmenich SA, 1 route des Jeunes, 8 1211 Geneva, Switzerland.
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MeSH Terms
Flavoring Agents / adverse effects*,  analysis*
Models, Statistical
Plant Extracts / adverse effects,  analysis
Stochastic Processes
United States
Reg. No./Substance:
0/Flavoring Agents; 0/Plant Extracts

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