| Novel effects of nitric oxide. | |
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MedLine Citation:
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PMID: 11264456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many of these effects. However, NO can also interact with molecular oxygen and superoxide radicals to produce reactive nitrogen species that can modify a number of macromolecules including proteins, lipids, and nucleic acids. NO can also interact directly with transition metals. Here, we have reviewed the non--3',5'-cyclic-guanosine-monophosphate-mediated effects of NO including modifications of proteins, lipids, and nucleic acids. |
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Authors:
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K L Davis; E Martin; I V Turko; F Murad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annual review of pharmacology and toxicology Volume: 41 ISSN: 0362-1642 ISO Abbreviation: Annu. Rev. Pharmacol. Toxicol. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-03-26 Completed Date: 2001-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7607088 Medline TA: Annu Rev Pharmacol Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 203-36 Citation Subset: IM; S |
Affiliation:
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Department of Integrated Biology and Pharmacology, University of Texas Houston Health Science Center, Houston, Texas 77030, USA. karen.l.davis@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Metals / metabolism Nitric Oxide / chemistry, pharmacology*, physiology Proteins / chemistry, drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL10046-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Proteins; 10102-43-9/Nitric Oxide |
| Investigator | |
Investigator/Affiliation:
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F Murad / U TX Health Sci Ctr, Houston |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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